Leptin
The discovery of leptin more than a decade ago was a major turning point in our understandingof adipokines. Mice and humans homozygous for the leptin gene mutationdevelop hyperphagia, severe early-onset obesity, insulin resistance preceding obesity,excess lipid accumulation outside adipose tissue (steatosis), and neuroendocrine abnormalities,notably, hypothalamic hypogonadism and tertiary hypothyroidism.Moreover, there is evidence for immunosuppression...
